1907 – Against the Reds, New York jumps to a 6 – 0 lead against Charlie Smith, and Christy Mathewson coasts to a 6 – 2 win. Fred Merkle makes his first appearance for the Giants, playing 2B.

This Day In Baseball

On September 21, 1907 — 1907 – Against the Reds, New York jumps to a 6 – 0 lead against Charlie Smith, and Christy Mathewson coasts to a 6 – 2 win. Fred Merkle makes his first appearance for the Giants, playing 2B.

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Sources:
Baseball Reference September 21
National Pastime September 21
Retro Sheet
Hall of Fame
SABR Games Project
Replay The Game