1921 – At the Polo Grounds, the Yankees thrash the 2nd-place Indians, 21 – 7, to move a full game ahead of the Tribe. The Yanks knock out Ray Caldwell in the 2nd and dust Duster Mails for 10 runs in his two innings. Carl Mays goes the distance for the win.

This Day In Baseball

On September 25, 1921 — 1921 – At the Polo Grounds, the Yankees thrash the 2nd-place Indians, 21 – 7, to move a full game ahead of the Tribe. The Yanks knock out Ray Caldwell in the 2nd and dust Duster Mails for 10 runs in his two innings. Carl Mays goes the distance for the win.

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Sources:
Baseball Reference September 25
National Pastime September 25
Retro Sheet
Hall of Fame
SABR Games Project
Replay The Game