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Andy Pettitte is hit by a line drive during warmups and struggles through a 5-3 loss to St. Louis in Game One of the N.L.C.S. Reggie Sanders powers a two-run blast in the first off Pettitte as the Cardinals build a lead they would never surrender. Chris Burkestays hot for Houston with a pinch-hit two-run shot of his own. 

On October 12 , 2005 – Andy Pettitte is hit by a line drive during warmups and struggles through a 5-3 loss to St. Louis in Game One of the N.L.C.S. Reggie Sanders powers a two-run blast in the first off Pettitte as the Cardinals build a lead they would never surrender. Chris Burkes tays hot for Houston with a pinch-hit two-run shot of his own. Chris Carpenter is the winning pitcher,