On September 17 , 2011 — 2011 – With a 2-1 loss to the Cubs at Wrigley Field, the Astros suffer the first 100-loss season in their 50-year history. For trivia buffs, the decisive run came in the fourth when rookie Bryan LaHair homered off rookie Henry Sosa. Houston would finish the season with the worst record in the majors at 56-106. 


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