At American League Park, the New York Highlanders lose their first game to the Washington Senators, 3 – 1, before 11,950 fans. Washington elects to bat first, but the New Yorkers score in the bottom of the opening inning to take a 1 – 0 lead. Each starter gives up six hits with Jack Chesbro, the National League’s top winner last year (28-6) taking the loss. Al Orth, in his second season with Washington, is the winner.

This Day In Baseball

On April 22, 1903 — At American League Park, the New York Highlanders lose their first game to the Washington Senators, 3 – 1, before 11,950 fans. Washington elects to bat first, but the New Yorkers score in the bottom of the opening inning to take a 1 – 0 lead. Each starter gives up six hits with Jack Chesbro, the National League’s top winner last year (28-6) taking the loss. Al Orth, in his second season with Washington, is the winner.

Source
Baseball Reference April 22