On September 24, 1940 — At Shibe Park, Red Sox first baseman Jimmie Foxx blasts his 500th career home run off A’s pitcher George Caster. The historic homer is one of four round-trippers hit in the inning, setting an American League mark.

 


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Sources:
Baseball Reference September 24
National Pastime September 24
Retro Sheet
Hall of Fame
SABR Games Project
Replay The Game