Barry Bonds of the San Francisco Giants hits the 12,000th home run in Giants history. The home run comes off Colorado Rockies pitcher Denny Neagle in the 1st inning of a Giants 5 – 4 victory at Pacific Bell Park.

On May 27, 2001 — Barry Bonds of the San Francisco Giants hits the 12,000th home run in Giants history. The home run comes off Colorado Rockies pitcher Denny Neagle in the 1st inning of a Giants 5 – 4 victory at Pacific Bell Park.

Source:
Baseball Reference May 27