Cy Young Award winner Johan Santana ends his 17-game winning streak in the Minnesota Twins’ 2 – 1 loss to the Los Angeles Angels. Santana strikes out seven over eight innings and allows just two hits, but they are solo home runs by Vladimir Guerrero and Jose Molina.

On May 1, 2005 — Cy Young Award winner Johan Santana ends his 17-game winning streak in the Minnesota Twins’ 2 – 1 loss to the Los Angeles Angels. Santana strikes out seven over eight innings and allows just two hits, but they are solo home runs by Vladimir Guerrero and Jose Molina.

Source
Baseball Reference May 1