In Chicago, the Giants’ Hooks Wiltse, with relief help from Christy Mathewson, stops the leading Cubs, 6 – 4. Mathewson allows one run in his four innings.

On May 21, 1906 — In Chicago, the Giants’ Hooks Wiltse, with relief help from Christy Mathewson, stops the leading Cubs, 6 – 4. Mathewson allows one run in his four innings.

Source:
Baseball Reference May 21