lou gehrig 4 homeruns in a game On June 3, 1932, Lou Gehrig of the New York Yankees becomes the first 20th century major leaguer to hit four home runs in a single game. The “Iron Horse” achieves the milestone against the Philadelphia Athletics, helping the Yankees to a 20-13 victory. Gehrig comes close to hitting a fifth home run in his final at-bat, hitting a deep fly ball that is caught at the fence by A’s left fielder Al Simmons.