Manny Ramirez hits a two-run home run and a grand slam to knock in all of Boston’s runs in a 6 – 2 victory against Tampa Bay. Matt Clement wins in his Fenway Park debut. It is Ramirez’s 18th career grand slam, most among active players. The blast ties him for third on the all-time list with Willie McCovey and Robin Ventura, behind only Eddie Murray (19) and Lou Gehrig (23). It is Ramirez’s 40th career multi-homer game (38 two-homer games, two three-homer games).

On April 16, 2005 — Manny Ramirez hits a two-run home run and a grand slam to knock in all of Boston’s runs in a 6 – 2 victory against Tampa Bay. Matt Clement wins in his Fenway Park debut. It is Ramirez’s 18th career grand slam, most among active players. The blast ties him for third on the all-time list with Willie McCovey and Robin Ventura, behind only Eddie Murray (19) and Lou Gehrig (23). It is Ramirez’s 40th career multi-homer game (38 two-homer games, two three-homer games).

Source
Baseball Reference April 16