Miguel Cabrera hits the 400th home run of his career off Tyler Lyons in the 1st inning of a game against the Cardinals. With the blast, he passes both Andres Galarraga, who held the record for most homers by a player from Venezuela, and Detroit Tigers legend Al Kaline, who both finished with 399 homers. The homer comes one night after Adrian Beltre also reached the 400 mark. The Tigers win, 4 – 3, in 10 innings.

On May 16, 2015 — Miguel Cabrera hits the 400th home run of his career off Tyler Lyons in the 1st inning of a game against the Cardinals. With the blast, he passes both Andres Galarraga, who held the record for most homers by a player from Venezuela, and Detroit Tigers legend Al Kaline, who both finished with 399 homers. The homer comes one night after Adrian Beltre also reached the 400 mark. The Tigers win, 4 – 3, in 10 innings.

Source:
Baseball Reference May 16