On April 4, 1999 — Opening Day takes place in Mexico, making it the first time that the major league season’s first pitch comes outside the United States or Canada, as the Colorado Rockies defeat the National League defending champs, the San Diego Padres.

 


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Sources:
Baseball Reference April 4
National Pastime April 4
Retro Sheet
Hall of Fame
SABR Games Project
Replay The Game