Rickey Henderson leads off with a home run, extending his major-league record for leadoff home runs to 79. This is more than the combined total for the #2 and #3 players on the list: Brady Anderson (44), and Bobby Bonds(35).

This Day In Baseball

On May 16, 2001 — Rickey Henderson leads off with a home run, extending his major-league record for leadoff home runs to 79. This is more than the combined total for the #2 and #3 players on the list: Brady Anderson (44), and Bobby Bonds(35).

Source:
Baseball Reference May 16