On August 15, 1961 — Roger Maris hits his 46th homer, off Chicago’s Juan Pizarro, for New York’s only run in a 2 – 1 loss to the visiting White Sox. Pizarro allows just four hits. Whitey Ford loses in his bid for his 21st win.

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Source:
Baseball Reference August 15
National Pastime
Retro Sheet
Hall of Fame
SABR Games Project
Replay The Game