San Francisco Giants left fielder Barry Bonds becomes the first player to hit a ball into San Francisco Bay (McCovey’s Cove) as the first “splashdown” home run at Pacific Bell Park helps the Giants beat the Mets, 10 – 3.

On May 1, 2000 — San Francisco Giants left fielder Barry Bonds becomes the first player to hit a ball into San Francisco Bay (McCovey’s Cove) as the first “splashdown” home run at Pacific Bell Park helps the Giants beat the Mets, 10 – 3.

Source
Baseball Reference May 1