The Colorado Rockies defeat the St. Louis Cardinals, 7 – 6. Mark McGwire and Fernando Tatis hit home runs for St. Louis as the Cardinals set a National League mark for most home runs in the month of April with 42.

This Day In Baseball

On April 22, 2000 — The Colorado Rockies defeat the St. Louis Cardinals, 7 – 6. Mark McGwire and Fernando Tatis hit home runs for St. Louis as the Cardinals set a National League mark for most home runs in the month of April with 42.

Source
Baseball Reference April 22