With the Yankees trailing by three runs in the bottom of the tenth inning, Babe Ruth hits a Sarge Connally pitch for a game-winning home run which beats the White Sox, 6-5. The ‘Sultan of Swat’ becomes the first modern player to blast a walk-off homer with the bases full which wins the game by one run.

On September 24, 1925 — With the Yankees trailing by three runs in the bottom of the tenth inning, Babe Ruth hits a Sarge Connally pitch for a game-winning home run which beats the White Sox, 6-5. The ‘Sultan of Swat’ becomes the first modern player to blast a walk-off homer with the bases full which wins the game by one run.


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Sources:
Baseball Reference September 24
National Pastime September 24
Retro Sheet
Hall of Fame
SABR Games Project
Replay The Game