1889 – New York Giants pitcher Mickey Welch strikes out as the first pinch hitter in major league history.

On September 10, 1889 — 1889 – New York Giants pitcher Mickey Welch strikes out as the first pinch hitter in major league history.


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Sources:
Baseball Reference September 10
National Pastime September 10
Retro Sheet
Hall of Fame
SABR Games Project
Replay The Game