1911 – The Detroit Tigers lose their first home game of the year, 6 – 2, as New York hands George Mullin his first loss. The Tigers have a 21 – 2 record and will lead the pack until July 4th.

On May 10, 1911 — 1911 – The Detroit Tigers lose their first home game of the year, 6 – 2, as New York hands George Mullin his first loss. The Tigers have a 21 – 2 record and will lead the pack until July 4th.

Source:
Baseball Reference May 10