An ailing Lou Gehrig hits his 493rd and final major league home run off Senators’ right-hander Dutch Leonard. On the same date 15 years earlier, the Yankee first baseman had gone deep off Bill Piercy at Fenway Park for his first career home run.

On September 27, 1938 — An ailing Lou Gehrig hits his 493rd and final major league home run off Senators’ right-hander Dutch Leonard. On the same date 15 years earlier, the Yankee first baseman had gone deep off Bill Piercy at Fenway Park for his first career home run.

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Sources:
Baseball Reference September 27
National Pastime September 27
Retro Sheet
Hall of Fame
SABR Games Project
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