On September 27, 1938 — An ailing Lou Gehrig hits his 493rd and final major league home run off Senators’ right-hander Dutch Leonard. On the same date 15 years earlier, the Yankee first baseman had gone deep off Bill Piercy at Fenway Park for his first career home run.

 


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Sources:
Baseball Reference September 27
National Pastime September 27
Retro Sheet
Hall of Fame
SABR Games Project
Replay The Game