On September 7, 1967 ā At Candlestick Park, the Giants tie a National League mark, using a record 25 players to beat the Astros in 15 innings, 3-2. Manager Herman Franks uses all his starters and five relief pitchers, sends six pinch hitters to the plate, and three players enter the contest as pinch runners, along with two defensive substitutions.
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Sources:
Baseball Reference September 7
National Pastime
Retro Sheet
Hall of Fame
SABR Games Project
Replay The Game