On May 8, 1903 — Chicago White Sox pitcher Nixey Callahan gets five hits for the third time in his career (also June 29, 1897 and May 18, 1902), but the 11-inning loss to the St. Louis Brownsis the final game he will pitch in the major leagues. He will play other positions until 1913. Nixey is the only pitcher ever to garner five hits three times.

Source:
Baseball Reference May 8