On April 22, 1991 — During the first night game in the new ballpark, Frank Thomas hits the first White Sox home run in Comiskey Park, contributing to Chicago’s 8-7 victory over Baltimore. In the south-side stadium debut three days ago, Jack McDowell surrendered the park’s first homer to Cecil Fielder in a 16-0 rout of the home team by Detroit.
Source:
National Pastime