On April 22, 2012 — Jordan Schafer hits his first career grand slam off the Dodgers’ Chad Billingsley, who had already given up a two-run shot to Carlos Lee in the 1st. Staked to this comfortable early lead, Wandy Rodriguez cruises to a 12 – 0 win for the Astros, allowing only 3 hits in 7 innings.
Source
Baseball Reference April 22