On August 28, 2009 — Pinch-hitting in the 6th inning, John Hester hits a home run in his first major league at bat to help Arizona beat Houston, 14 – 7. He hits the homer off Wilton Lopez, who is also making his major league debut.
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Sources:
Baseball Reference August 28
National Pastime August 28
Retro Sheet
Hall of Fame
SABR Games Project
Replay The Game