On September 13, 1965 — 1965 – At the Astrodome facing Don Nottebart, Giant outfielder Willie Mays becomes the fifth player in major league history to hit 500 career home runs. The “Say Hey Kid” will hit a league-leading and career-high 52 home runs en route to his second MVP season. Juan Marichal gets his 22nd victory, a 5 – 1 decision over Houston. It is the 11th straight win for San Francisco, which now has a 2 1/2 game lead in the National League pennant race.


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