On September 13, 1965 – At the Astrodome facing Don Nottebart, Giant outfielder Willie Mays becomes the fifth player in major league history to hit 500 career home runs. The “Say Hey Kid” will hit a league-leading and career-high 52 home runs en route to his second MVP season. Juan Marichal gets his 22nd victory, a 5 – 1 decision over Houston. It is the 11th straight win for San Francisco, which now has a 2 1/2 game lead in the National League pennant race.

The other players with 500 homeruns:

Babe Ruth August 11, 1929
Jimmie Foxx September 24, 1940
Mel Ott August 1, 1945
Ted Williams June 17, 1960

Mays would become the first African-American and first former Negro Leaguer to reach the 500 home run plateau. Mays would pass Mel Ott on both the All-Time National League home run list on May 4, 1966. Mays would remain the National League All-Time hit list until he was passed by Hank Aaron on June 10, 1972.

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