On April 5, 1988 — With a 6-3 Opening Day victory over the Padres, Houston wins its 2,000th game in franchise history. The Astros score five runs in the bottom of the eighth inning, making starter Mike Scott the winning pitcher.
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Sources:
Baseball Reference April 5
National Pastime April 5
Retro Sheet
Hall of Fame
SABR Games Project
Replay The Game