White Sox beat the Astros in their first World Series game in 43 year history of the franchise

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On October 22, 2005 — In the World Series opener, Jose Contreras pitches seven solid innings, then relievers Neal Cotts and Bobby Jenks combine for two scoreless innings – getting five of the last six outs on strikeouts – as the Chicago White Sox defeat the Houston Astros, 5 – 3, at U.S. Cellular Field. Joe Crede and Jermaine Dye hit home runs for Chicago.

In the first World Series game of the 43-year history of the Houston Astros, 43-year-old Roger Clemens starts for the Astros but lasts only two innings in a 5-3 loss to the Chicago White Sox, with a strained left hamstring, the same injury that caused him to miss a start in late September. While registering 92 mph on his fastball, he struggles, allowing three runs on four hits in the two innings and leaves after throwing 54 pitches.

Mike Lamb homers and Lance Berkman spanks a two-run double to highlight the Houston attack. On two occasions, speedy Willy Taveras leads off an inning with an extra-base hit but the heart of the Astros lineup cannot drive him in.
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