On May 18, 1961 — Los Angeles Angels pitcher Ryne Duren posts four strikeouts in the 7th inning against the Chicago White Sox. He strikes out Minnie Miñoso, Roy Sievers, J.C. Martin, and Sammy Esposito to tie a major league record, in the 6 – 4 loss to the White Sox.
Source:
Baseball Reference May 18