Jose Reyes returns to the line-up for the first time since May of last year as the Mets lose to the Nationals, 4 – 3. His injury was one of those that torpedoed the Mets’ 2009 season after a good start.

The Yankees’ CC Sabathia flirts with a no-hit bid, before giving up a two-out single to the Rays’ Kelly Shoppach in the 8th inning. Having reached his pitch count limit, he then exits the game, but is credited with the Yanks’ 10 – 0 win.

After four days of weather-induced postponements, including blinding snow and sub-freezing temperatures, the Cleveland Indians play their home opener on the road, beating the Angels at Miller Park in Milwaukee, 7-6. The last time a series changed venues, the games were played in U.S. Cellular Field when the Marlins hosted the Expos in Chicago due to Hurricane Ivan hitting Miami in September of 2004.

Jim Thome and Joe Crede hit two-run home runs and Paul Konerko adds a solo shot, leading the Chicago White Sox to a 5 – 3 victory in the Detroit Tigers’ home opener. Freddy Garcia strikes out five and limits the Tigers to five hits in six innings en route to his 100th career victory.

Howdy Groskloss, a former Pittsburgh Pirates infielder, celebrates his 100th birthday this week, making him the oldest living major league baseball player.

During the Devil Rays’ home opener, a snippet of More Cowbell, a skit from Saturday Night Live, originally aired in the spring of 2000, is shown at Tropicana Field. The use of the video clip, suggested by the team’s new principal owner Stuart Sternberg, will inspire the Tampa Bay fans to start the tradition of clanging bells at the ballpark during games.

David Ortiz agrees to a four-year contract extension with the Boston Red Sox, a deal that will guarantee the slugger about $52 million. In 2005, Ortiz batted .300 with 148 RBI in 159 games, as his 47 home runs were second in Red Sox history to Jimmie Foxx’s 50 in 1938.

Astros’ outfielder Craig Biggio breaks Bobby Bonds’ National League record when he hits his 31st career leadoff homer, a shot off Cincinnati’s Danny Graves in Houston’s 4-2 victory at Minute Maid Park. Rickey Henderson holds the major league mark, homering 80 times as the first batter for his team.

In a 7 – 6 victory over the Cardinals at Coors Field, the Colorado Rockies turn the first triple play in club history. With Scott Rolen on second base and Tino Martinez on first, Colorado first baseman Todd Helton catches Orlando Palmeiro’s soft liner for the first out and throws to shortstop Jose Hernandez who steps on second for the second out and then tags Martinez to complete the feat.