Tim Wakefield takes the mound for the Red Sox at age 44 years and 282 days. He breaks Deacon McGuire’s record as the oldest performer in Boston Red Sox history – McGuire was 44 years and 280 days old on August 24, 1908, his last game for the franchise.

Johnny Cueto comes within about a foot of a no-hitter when SS Paul Janish dives to stop Ronny Cedeno’s ground ball in the 3rd inning, only to see it deflect off his glove for a single. That’s the only base hit for the Pirates, as the Reds hurler records a 9 – 0 one-hitter. Chris Heisey gets his first three major league hits in the game, including a home run.

The Mariners’ key acquisition during the off-season, left-handed pitcher Cliff Lee, finally wins a game for his new team. After spending all of April on the disabled list with a strained abdominal muscle, and pitching well in his first two starts but being let down by an anemic offense, he pitches 7 1/3 strong innings in a 5 – 1 win over the Orioles. Brandon League then relieves Lee and finishes the game to earn his first save of the year, while Ryan Langerhans homers off loser David Hernandez, who is now 0-5.

In their first game since Dallas Braden’s perfect game, the A’s have to use 6 relievers to grind out a 7 – 6 win over the Rangers in 13 innings. Daric Barton drives in Landon Powell, who had just stolen his first major league base on a busted hit-and-run play, for the winning run. Barton had earlier homered in the 11th, only to see Texas come back against Tyson Ross for the third blown save by an A’s reliever on the night. Ross then strikes out when forced to bat in the 12th because of an empty Oakland bench, and later gets credit for his first major league win.

Ryan Zimmerman goes 4 for 5 with two home runs to extend his hitting streak to 29 games, but San Francisco beats Washington, 11 – 7. Randy Johnson strikes out nine for career win number 298. The game features the tallest pitching match-up in history, with the 6′ 10″ Johnson facing Daniel Cabrera, who stands 6′ 9″.

The Colorado Springs SkySox top the Albuquerque Isotopes, 5 – 1. The game is historic in that it is the first no-hitter ever thrown at home by the SkySox. Franklin Morales walks six in five hitless innings and is relieved in turn by Chris George (1 2/3 IP, 2 BB), Matt Daley (1 1/3 IP, 1 BB) and Steven Register (1 IP, no BB) as the Isotopes get nine walks but no hits.

At Shea Stadium, a 13-minute delay occurs in the beginning of the ninth of the Mets’ 8-3 victory over the Reds, when David Ross bats out of order, making an out in Corey Patterson’s place in the lineup. The very confused umpires eventually make the correct call, telling Ross to bat again, now with one out, without his teammate having an opportunity to come to the plate.

Hideki Matsui’s streak of playing in every game since starting his MLB career with the Yankees in 2003 ends at 518 games as the left fielder breaks his left wrist attempting to make a diving catch. The 31 year-old Japanese star established the big league record for consecutive games to start a career, surpassing Hall of Fame infielder Ernie Banks, who played in 424 contests at the start of his playing days with Cubs from 1953-56.